Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition
Amany M. Ghanim, Samar Rezq, Tarek S. Ibrahim, Damián G. Romero, Hend Kothayer
Topics & Concepts
ChemistryIC50CelecoxibArachidonate 5-lipoxygenasePharmacologyIn vitroEnzymeBiochemistryArachidonic acidBiologyInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis and Biological Evaluation