Basal Coronary Microvascular Resistance Predicting Death and Heart Failure in Patients Without Functional Coronary Stenosis
Tadashi Murai, Hiroyuki Hikita, Masao Yamaguchi, Aki Ito, Takayuki Warisawa, Hiroshi Ikeda, Ken Takahashi, Hirotaka Yano, Joonmo Chang, Takahiro Watanabe, Hiroshi Yoshikawa, Yoshinori Kanno, Keiichi Hishikari, Atsushi Takahashi, Hiroyuki Fujii, Taishi Yonetsu, Tetsuo Sasano, T Kakuta
Abstract
BACKGROUND: Abnormal coronary microcirculation is linked to poor patient prognosis, so the aim of the present study was to assess the prognostic relevance of basal microvascular resistance (b-IMR) in patients without functional coronary stenosis. METHODS AND RESULTS: =4.420; P=0.036). Incorporating b-IMR into a clinical model that included CFR improved the Net Reclassification Index and Integrated Discrimination Improvement for predicting the primary endpoints (P<0.001 and P=0.034, respectively). CONCLUSIONS: b-IMR may be a specific marker of the risk of death and heart failure in patients without functional coronary stenosis.