Myopathic Cardiac Genotypes Increase Risk for Myocarditis
Amy Kontorovich, Nihir Patel, Arden Moscati, Felix Richter, Inga Peter, Enkhsaikhan Purevjav, Simina Selejan, Ingrid Kindermann, Jeffrey A. Towbin, Michael Böhm, Karin Klingel, Bruce D. Gelb
Abstract
Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac genes were found in 19 of 117 acute myocarditis cases vs 34 of 468 control subjects (P = 0.003). Thirteen genes classically associated with cardiomyopathy or neuromuscular disorders with cardiac involvement were implicated, including >1 associated damaging variant in DYSF, DSP, and TTN. Phenotypes of subjects who have acute myocarditis with or without deleterious variants were similar, indicating that genetic testing is necessary to differentiate them.