Status check: next-generation sequencing for infectious-disease diagnostics
Kyle G. Rodino, Patricia J. Simner
Abstract
Next-generation sequencing (NGS) applications for the diagnostics of infectious diseases has demonstrated great potential with three distinct approaches: whole-genome sequencing (WGS), targeted NGS (tNGS), and metagenomic NGS (mNGS, also known as clinical metagenomics). These approaches provide several advantages over traditional microbiologic methods, though challenges still exist.
Topics & Concepts
MetagenomicsDNA sequencingComputational biologyInfectious disease (medical specialty)Whole genome sequencingGenomeBiologyDiseaseMedicineGeneticsDNAGenePathologyGenomics and Phylogenetic StudiesMycobacterium research and diagnosisMicrobial infections and disease research