Water-Sculpting of a Heterogeneous Nanoparticle Precatalyst for Mizoroki–Heck Couplings under Aqueous Micellar Catalysis Conditions
Haobo Pang, Yuting Hu, Tzu‐Yu Yu, Fabrice Gallou, Bruce H. Lipshutz
Abstract
P-ligated Pd occur under aqueous micellar catalysis conditions between room temperature and 45 °C, and show broad substrate scope. Other key features associated with this new technology include low residual Pd in the product, recycling of the aqueous reaction medium, and an associated low E Factor. Synthesis of the precursor to galipinine, a member of the Hancock family of alkaloids, is suggestive of potential industrial applications.
Topics & Concepts
ChemistryAqueous solutionCatalysisNanoparticleChemical engineeringOrganic chemistryEngineeringCatalytic Cross-Coupling ReactionsNanomaterials for catalytic reactionsChemical Synthesis and Reactions