Near-Infrared Light-Driven Efficient Tumor Elimination via Strong Oxidative Photogenerated Holes in Donor–Acceptor Supramolecular Porphyrin
Wenting Li, Jianfang Jing, Ziyu Wei, Jingyi Xu, Wenhao Shi, Huaipeng Wang, Xiaolin Zhu, Yan Du, Yifei Wang, Junshan Li, Yongfa Zhu
Abstract
High Resolution Image Download MS PowerPoint Slide Efficient photocatalytic tumor therapy relies on deep tissue penetration via near-infrared (NIR) light absorption and potent oxidative stress induced by efficient photogenerated hole (h + ) migration. Herein, we report a supramolecular donor–acceptor (D–A) structure fabricated by integrating self-assembled tetra(4-carboxyphenyl) porphyrin (SA-TCPP) with amino-functionalized graphene quantum dots (GQDs-NH 2 ). The D–A configuration significantly narrowed the band gap for extended NIR absorption and amplified the interfacial electric field 6.2 times. This facilitated efficient h + migration with a 5.3-fold enhancement, generating highly oxidation holes. Under 700 nm irradiation, this system induced potent oxidative cell apoptosis, leading to 100% tumor elimination in vivo . This study presents a dual-promotion strategy involving NIR responsiveness and charge migration, advancing the efficiency of photocatalytic cancer therapy.