Rhodium(<scp>iii</scp>)-catalyzed asymmetric [4+1] spiroannulations of <i>O</i>-pivaloyl oximes with α-diazo compounds
Lincong Sun, Bingxian Liu, Yanlian Zhao, Junbiao Chang, Lingheng Kong, Fen Wang, Wei Deng, Xingwei Li
Abstract
catalysts can catalyze the asymmetric [4+1] spiroannulation of O-pivaloyl oximes with α-diazo homophthalimides under redox-neutral and acid/base-neutral conditions, leading to formation of chiral spirocyclic imines as a result of C-H activation and N-O cleavage. The reaction proceeded with high efficiency and features broad substrate scope, mild reaction conditions, and high to excellent enantioselectivities.
Topics & Concepts
DiazoEnantioselective synthesisRhodiumChemistryCatalysisStereochemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions