DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts
Raffaella Spina, Ian Mills, Fahim Ahmad, Chixiang Chen, Heather M. Ames, Jeffrey A. Winkles, Graeme F. Woodworth, Eli E. Bar
Topics & Concepts
BiologyDihydroorotate dehydrogenaseCancer researchGliomaStem cellDNA damageCell growthCell cycleDNA repairApoptosisCell biologyDNAGeneticsPyrimidineGlioma Diagnosis and TreatmentBiochemical and Molecular ResearchCancer, Hypoxia, and Metabolism