Asymmetric synthesis of acyclic N–N axially chiral indole compounds <i>via</i> catalytic <i>N</i>-acylation reaction
Zilu Huang, Yunyi Xu, Wei Lin, Rui Qian, Wei Zhang, Xin Li
Abstract
Herein, we present an enantioselective synthesis of N -aminoindoles bearing a N–N axis via chiral isothiourea catalyzed asymmetric N -acylation. Notably, some of the products exhibited promising cytotoxicity activities against some cancer cell lines.
Topics & Concepts
ChemistryAcylationEnantioselective synthesisCatalysisIndole testCombinatorial chemistryStereochemistryOrganic chemistryAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySphingolipid Metabolism and Signaling