Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy (Adv. Mater. 29/2024)
Shufen Xu, Yue Xu, Nicholas C. Solek, Jingan Chen, Fanglin Gong, Andrew Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, Bowen Li
Abstract
Inhalable RNA Immunotherapy In article number 2400307, Bowen Li and co-workers develop a tumor-tailored lipid nanoparticle system to deliver IL-12 circular RNA for enhanced lung cancer immunotherapy. Inhalation of these engineered nanoparticles can effectively induce immune activation, increase CD8+ T cell infiltration into tumor tissues, and lead to lung tumor regression, offering a promising strategy to improve treatment outcomes of lung cancer.
Topics & Concepts
Materials scienceImmunotherapyLung cancerLung tumorCancer immunotherapyNanoparticleCancerCancer researchNanotechnologyRNAMedicineOncologyBiochemistryInternal medicineBiologyGeneRNA Interference and Gene DeliveryCircular RNAs in diseasesNanoplatforms for cancer theranostics