Blockade of 5-HT<sub>2</sub>receptors suppresses rate of torque development and motor unit discharge rate during rapid contractions
Benjamin I. Goodlich, Sean A. Horan, Justin J. Kavanagh
Abstract
We have shown that serotonin activity in the central nervous system plays a role in regulating human motor unit discharge rate during rapid contractions. Our findings support the viewpoint that serotonergic effects in the central nervous system are fast and are most prominent during contractions that are characterized by high motor unit discharge rates and large amounts of torque development.
Topics & Concepts
Motor unitCyproheptadineSerotonergicSerotoninMotor unit recruitmentMuscle contractionChemistryContraction (grammar)Internal medicineNeurosciencePsychologyAnesthesiaEndocrinologyMedicineElectromyographyReceptorMuscle activation and electromyography studiesTranscranial Magnetic Stimulation StudiesNeuroscience and Neural Engineering