Mitochondrial Protein UCP1 Inhibits the Malignant Behaviors of Triple-negative Breast Cancer through Activation of Mitophagy and Pyroptosis
Jing Xia, Changbin Chu, Wanqing Li, Hong Chen, Wenhua Xie, Rui Cheng, Kai Hu, Xi Li
Abstract
. Our results suggested that UCP1 could inhibit the process of TNBC by activating mitophagy and pyroptosis. Impaired activation of mitophagy weakens the regulation effect of UCP1 on metastasis of TNBC, similar to the impairment of GSDME activation on the proliferation regulation of UCP1 on TNBC. UCP1 might be a novel therapeutic target of TNBC.
Topics & Concepts
MitophagyTriple-negative breast cancerCancer researchCarcinogenesisMitochondrionPyroptosisAutophagyChemistryMetastasisCell biologyBreast cancerBiologyCancerApoptosisProgrammed cell deathMedicineInternal medicineBiochemistryMitochondrial Function and PathologyAdipose Tissue and MetabolismAutophagy in Disease and Therapy