Bioreactor-scale cell performance and protein production can be substantially increased by using a secretion signal that drives co-translational translocation in Pichia pastoris
Juan J. Barrero, Alejandro Pagazartaundua, Benjamin S. Glick, Francisco Valero, Pau Ferrer
Topics & Concepts
SecretionSignal peptidePichia pastorisBiologySecretory proteinCell biologySecretory pathwayLipaseChromosomal translocationBiochemistryRecombinant DNAEndoplasmic reticulumGolgi apparatusEnzymeGeneFungal and yeast genetics researchCellular transport and secretionEndoplasmic Reticulum Stress and Disease