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Recent Advances of Enaminones in Multi‐component Reactions: A Brief Review

Yuan Qu, Fuchun Yang, Yu Han, Feng Feng, Chengyu Wang

2025European Journal of Organic Chemistry13 citationsDOIOpen Access PDF

Abstract

Abstract As we know, multicomponent reactions have emerged as powerful tools in organic synthesis due to their high atom and step economy, eco‐friendly, diversity, convenience, and cost‐effectiveness, and have broad application prospects in many fields such as drug synthesis, material science and natural product synthesis. On the other side, enaminones, which contain amine‐alkene‐carbonyl conjugated structure possessing multiple reactive sites, have extensively served as versatile building blocks for the construction of diverse organic molecules. In this review, we describe recent advances in enaminones involved multi‐component reactions (MCRs). Commonly synthetic strategies, reaction conditions, substrate scopes, reaction features, and the proposed mechanisms of each cited paper were nearly all discussed, and their future outlook is also prospected.

Topics & Concepts

ChemistryComponent (thermodynamics)NanotechnologyThermodynamicsMaterials sciencePhysicsSynthesis of heterocyclic compoundsSynthesis and Characterization of Heterocyclic CompoundsMulticomponent Synthesis of Heterocycles