In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis
Gabriel Matos‐Rodrigues, Vilma Barroca, Ali‐Akbar Muhammad, Elodie Dardillac, Awatef Allouch, Stéphane Koundrioukoff, Daniel Lewandowski, Emmanuelle Despras, Josée Guirouilh‐Barbat, Lucien Frappart, Patricia Kannouche, P. Dupaigne, Éric Le Cam, Jean‐Luc Perfettini, Paul‐Henri Roméo, Michelle Debatisse, Maria Jasin, Gabriel Livera, Emmanuelle Martini, Bernard S. López
Topics & Concepts
RAD51BiologyCarcinogenesisHomologous recombinationDNA repairDNA damageProgenitor cellCancer researchProgenitorGenome instabilityCancerIn vivoCell biologyGeneticsStem cellGeneDNADNA Repair MechanismsPARP inhibition in cancer therapyCRISPR and Genetic Engineering