Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy
Lauren Richardson, Ananth Kumar Kammala, Maged M. Costantine, Stephen J. Fortunato, Enkhtuya Radnaa, Sungjin Kim, Robert N. Taylor, Arum Han, Ramkumar Menon
Abstract
: Two distinct feto-maternal interface OOCs were developed, tested, and validated for their utility to conduct preclinical trials during pregnancy. We demonstrated that the placenta and fetal membranes-decidual interface both are able to transport and metabolize drugs and that the safety and efficacy of a drug can be determined using the anatomical structures recreated on OOCs.
Topics & Concepts
PharmacokineticsInterface (matter)PharmacologyMedicineComputer scienceParallel computingBubbleMaximum bubble pressure methodPregnancy and Medication ImpactPregnancy and preeclampsia studiesPreterm Birth and Chorioamnionitis