Decreased Abundance of <i>Akkermansia muciniphila</i> Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes (Adv. Sci. 16/2021)
Jing Zhang, Yueqiong Ni, Lingling Qian, Qichen Fang, Tingting Zheng, Mingliang Zhang, Qiongmei Gao, Ying Zhang, Jiacheng Ni, Xuhong Hou, Yuqian Bao, Petia Kovatcheva‐Datchary, Aimin Xu, Huating Li, Gianni Panagiotou, Weiping Jia
Abstract
New Therapeutic Options for the Treatment of Diabetes In article number 2100536, Huating Li, Gianni Panagiotou, Weiping Jia, and co‐workers demonstrate lean patients with type 2 diabetes have distinct gut microbiota and bile acid profiles. The “Magician” Akkermansia muciniphila connects the gut to pancreas and liver by modulating 3β‐chenodeoxycholic acid and fibroblast growth factor 19, which sheds light on new therapeutic options for the prevention or treatment of diabetes. [Image: see text]
Topics & Concepts
Akkermansia muciniphilaDiabetes mellitusType 2 diabetesInternal medicineEndocrinologyGut floraFGF21Chenodeoxycholic acidMedicineInsulinAkkermansiaBile acidChemistryFibroblast growth factorImmunologyBiochemistryLactobacillusReceptorFermentationGut microbiota and healthPancreatic and Hepatic Oncology ResearchDigestive system and related health