Litcius/Paper detail

Advanced paternal age and risk of cancer in offspring

Yangyang Sun, Xu Li, Wei Jiang, Yuanming Fan, Qiong Ouyang, Wei Shao, Raphael N. Alolga, Yuqiu Ge, Gaoxiang Ma

2020Aging12 citationsDOIOpen Access PDF

Abstract

= 0.002). The subgroup analysis suggested that age, gender, smoking and BMI were related to the decreased cancer incidence of the respiratory and intrathoracic organs, lung and the female genitalia. Positive linear associations were observed between paternal age and cancer incidence of the female genitalia, respiratory and intrathoracic organs and the lungs. These findings indicate that advanced paternal age is an independent protective factor against various cancers in offspring.

Topics & Concepts

OffspringPaternal ageDemographyCancerMedicineBiologyGeneticsPregnancySociologyCancer Risks and FactorsBirth, Development, and HealthEpigenetics and DNA Methylation