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Solution-Phase Synthesis of a Base-Free Benzoborirene and a Three-Dimensional Inorganic Analogue

Hui Zhang, Junyi Wang, Weiguang Yang, Libo Xiang, Weicheng Sun, Wenbo Ming, Yinxin Li, Zhenyang Lin, Qing Ye

2020Journal of the American Chemical Society60 citationsDOI

Abstract

The base-free benzoborirene 1,2-BR-1,2-C6H4 (7) and its three-dimensional inorganic analogue 1,2-BR-1,2-C2B10H10 (13) have been successfully synthesized by Cp2ZrBr2 and LiCl elimination, respectively. The Cl analogue of the key intermediate for the formation of benzoborirene 7 has been isolated and structurally characterized, thus suggesting the reaction pathway via benzyne Zr complex formation, B–Br/Cbenzyne–Zr σ-bond metathesis, and a Cp2ZrBr2 elimination/ring-closing process. The rationality of the reaction pathway has been confirmed by DFT calculations. In addition, the title compounds shared the same reactivity pattern (i.e., 1,3-silyl migration) toward MeIiPr (8), thus allowing for the synthetic approach to the first carborane-substituted iminoborane 14.

Topics & Concepts

ChemistryAryneReactivity (psychology)SilylationStereochemistrySalt metathesis reactionMetathesisFree baseBase (topology)Ring (chemistry)Elimination reactionCombinatorial chemistryMedicinal chemistryCatalysisOrganic chemistryMathematical analysisPathologyPolymerAlternative medicinePolymerizationMedicineSalt (chemistry)MathematicsBoron Compounds in ChemistryOrganoboron and organosilicon chemistrySynthesis and Properties of Aromatic Compounds