Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma
Chengyao Chiang, Min Zhang, Dian Wang, Tian Xiao, Lizhi Zhu, Kai Chen, Junrong Huang, Jingying Huang, Jiang Zhu, Li Li, Cheng Chen, Yangchao Chen, Hongyi Hu, Wenqi Jiang, Yongdong Zou, Ting Wang, Duo Zheng
Abstract
The MKK3-p38 axis represents a potential therapeutic target for capsaicin. MKK3 phosphorylation might serve as a biomarker to identify NPC patients most likely to benefit from adjunctive capsaicin treatment.
Topics & Concepts
Nasopharyngeal carcinomaCapsaicinMedicineCancer researchPathologyOncologyInternal medicineRadiation therapyReceptorCancer Mechanisms and TherapyCell death mechanisms and regulationSynthesis and biological activity