Sequence-Based Genomic Analysis Reveals Transmission of Antibiotic Resistance and Virulence among Carbapenemase-Producing Klebsiella pneumoniae Strains
Yi Zhang, Chen Chen, Jing Wu, Jialin Jin, Tao Xu, Yang Zhou, Peng Cui, Jiazhen Chen, Shu Chen, Ning Jiang, Wenhong Zhang
Abstract
In this study, we combined genomic and epidemiological analyses and defined an optimal cutoff value for SNP difference that could be used to aid investigation in tertiary hospital in China. We revealed clonal transmission was the main cause of CP-Kpn infections in the hospital and identified four novel plasmids carrying virulence genes. Our results strongly suggested that dominant CP K. pneumoniae strains lead to outbreaks and described different evolutionary patterns of plasmids carrying multidrug resistance and virulence genes.
Topics & Concepts
Klebsiella pneumoniaeMicrobiologyVirulenceBiologyAntibiotic resistanceAntibioticsVirologySequence analysisGeneticsGeneEscherichia coliAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingBacteriophages and microbial interactions