The role of semaphorins in cardiovascular diseases: Potential therapeutic targets and novel biomarkers
Zheng Yin, Jishou Zhang, Shuwan Xu, Jianfang Liu, Yao Xu, Junping Yu, Mengmeng Zhao, Wei Pan, Menglong Wang, Jun Wan
Abstract
Semaphorins (Semas), which belongs to the axonal guidance molecules, include 8 classes and could affect axon growth in the nervous system. Recently, semaphorins were found to regulate other pathophysiological processes, such as immune response, oncogenesis, tumor angiogenesis, and bone homeostasis, through binding with their plexin and neuropilin receptors. In this review, we summarized the detailed role of semaphorins and their receptors in the pathological progression of various cardiovascular diseases (CVDs), highlighting that semaphorins may be potential therapeutic targets and novel biomarkers for CVDs.
Topics & Concepts
SemaphorinPlexinAxon guidanceSEMA3AAngiogenesisNeuroscienceNeuropilinNeuropilin 1ReceptorBiologyMedicineAxonCancer researchVascular endothelial growth factorVEGF receptorsBiochemistryAxon Guidance and Neuronal SignalingAngiogenesis and VEGF in CancerBiomarkers in Disease Mechanisms