Mixtures of persistent organic pollutants increase ovarian granulosa tumor cell line migration and spheroid invasion by upregulating MMP2 expression and activity via IGF1R
Justyna Gogola-Mruk, Marta Hoffmann, Kinga Kamińska, Anna Ptak
Topics & Concepts
SpheroidMMP2Insulin-like growth factor 1 receptorCell biologyCancer researchCell cultureChemistryBiologyDownregulation and upregulationInternal medicineMedicineGrowth factorReceptorGeneticsBiochemistryGeneEffects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsToxic Organic Pollutants Impact