Metal-free, visible-light driven C–H ketoalkylation of glycine derivatives and peptides
Hong Xin, Zi-Hang Yuan, Mingyu Yang, Minghua Wang, Xin‐Hua Duan, Li‐Na Guo
Abstract
A metal free, visible-light driven C–H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides diverse unnatural amino acids bearing a distal carbonyl group in moderate to good yields.
Topics & Concepts
GlycineChemistryAmino acidMetalVisible spectrumCombinatorial chemistryPeptideStereochemistryOrganic chemistryBiochemistryMaterials scienceOptoelectronicsCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques