Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters
Rayhanus Salam, Surid Mohammad Chowdhury, Sarah R. Marshall, Hassan Gneid, Nathalie Busschaert
Abstract
In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics of the transporters, this finding could not only have implications for drug delivery, but also hints towards potential drug-drug and drug-food interactions.
Topics & Concepts
TransporterChemistryDrugDrug deliveryPermeability (electromagnetism)Carboxylic acidMembraneMembrane permeabilityTransmembrane proteinVesicleBiophysicsMembrane transportLipid bilayerCombinatorial chemistryBiochemistryPharmacologyOrganic chemistryBiologyReceptorGeneDrug Transport and Resistance MechanismsLipid Membrane Structure and BehaviorMolecular Sensors and Ion Detection