Discovery of a novel small-molecule activator of SIRT3 that inhibits cell proliferation and migration by apoptosis and autophagy-dependent cell death pathways in colorectal cancer
Yi Mou, Yanmei Chen, Zhichao Fan, Liansong Ye, Bing Hu, Bo Han, Guan Wang
Topics & Concepts
AutophagyProgrammed cell deathCancer researchSIRT3Colorectal cancerApoptosisCarcinogenesisCell growthProtein kinase BCancer cellActivator (genetics)ChemistryCell biologyCancerBiologySignal transductionBiochemistryReceptorGeneticsSirtuinGeneAcetylationSirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism