AI-driven epitope prediction: a systematic review, comparative analysis, and practical guide for vaccine development
Francisca Villanueva‐Flores, Javier I. Sanchez-Villamil, Igor Garcia-Atutxa
Abstract
Integrating AI into epitope prediction is transforming vaccine design by delivering unprecedented accuracy, speed, and efficiency. This review synthesizes recent breakthroughs particularly CNNs, transformers, and GNNs highlighting experimentally validated models like MUNIS and GraphBepi that reveal previously overlooked epitopes. By benchmarking AI tools against traditional methods, we identify structural data integration as pivotal, offering practical strategies to translate computational predictions into actionable experimental workflows for next-generation vaccines.
Topics & Concepts
BenchmarkingEpitopeWorkflowComputer scienceArtificial intelligenceComputational biologyData scienceMachine learningBiologyImmunologyAntigenDatabaseBusinessMarketingvaccines and immunoinformatics approachesMachine Learning in BioinformaticsBacteriophages and microbial interactions