Gut-Testis Axis: Microbiota Prime Metabolome To Increase Sperm Quality in Young Type 2 Diabetes
Xiaowei Yan, Yanni Feng, Yanan Hao, Ruqing Zhong, Yue Jiang, Xiangfang Tang, Dongxin Lu, Hanhan Fang, Manjree Agarwal, Liang Chen, Yong Zhao, Hongfu Zhang
Abstract
A10-FMT benefits gut microbiota, liver function, and systemic environment via improvement in blood metabolome, consequently to favor the testicular microenvironment to improve spermatogenesis process and to boost T2D-diminished semen quality. We established that AOS-improved gut microbiota may be used to boost T2D-decreased semen quality and metabolic disease-related male subfertility.
Topics & Concepts
MetabolomeBiologySpermatogenesisSemen qualitySperm qualitySemenType 2 diabetesGut floraSpermDiabetes mellitusMetabolomicsEndocrinologyImmunologyBioinformaticsGeneticsUrinary Bladder and Prostate ResearchSperm and Testicular FunctionSexual function and dysfunction studies