Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
Pengcheng Zhang, Daniels Konja, Yiwei Zhang, Yu Wang
Abstract
Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.
Topics & Concepts
Endoplasmic reticulumMitochondrionHomeostasisCell biologyOrganelleBiologyEnergy homeostasisNutrient sensingMembrane contact siteAdaptation (eye)Signal transductionBiochemistryNeuroscienceMembrane proteinMembraneReceptorIntegral membrane proteinMitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseMetabolism and Genetic Disorders