Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis
Alexander Kremsmair, Johannes H. Harenberg, Kuno Schwärzer, Andreas Hess, Paul Knochel
Abstract
a direct metal insertion in the presence of LiCl or a Br/Mg-exchange using iPrMgCl·LiCl (turbo-Grignard) or related reagents. Alternatively, such functionalized organometallics are prepared by metalations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl). The scope of these methods is described as well as applications in new Co- or Fe-catalyzed cross-couplings or aminations. It is shown that the use of a continous flow set-up considerably expands the field of applications of these methods and further allows the preparation of highly reactive organosodium reagents.
Topics & Concepts
MagnesiumZincOrganic synthesisChemistryOrganic chemistryCombinatorial chemistryCatalysisCoordination Chemistry and OrganometallicsAsymmetric Synthesis and CatalysisSynthesis and characterization of novel inorganic/organometallic compounds