Exercise Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating Endoplasmic Reticulum Stress and Mitophagy Through M <sub>2</sub> Acetylcholine Receptor
Wei Chen, Mei Ma, Yinping Song, Yijie Hua, Hao Jia, Jiankang Liu, Youhua Wang, Jiankang Liu, Youhua Wang, Youhua Wang
Abstract
Aims: Adaptive changes in the heart by exercise have been shown to reduce the risk of cardiovascular disease, and M2 Acetylcholine receptor (M2AChR), a receptor abundantly present on cardiac parasympathetic nerves, is closely associated with the development of cardiovascular disease. The present study intends to investigate whether exercise can regulate endoplasmic reticulum stress (ERS) and mitophagy through M2AChR to resist myocardial ischemia-reperfusion (I/R) injury and to elucidate its mechanism of action.
Topics & Concepts
MitophagyEndoplasmic reticulumUnfolded protein responsePINK1Reperfusion injuryATF4EndocrinologyInternal medicineMedicineIschemiaSignal transductionCardiac function curveCHOPParkinApoptosisCell biologyChemistryBiologyAutophagyHeart failureParkinson's diseaseBiochemistryDiseaseEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyCardiac electrophysiology and arrhythmias