Dynamics of DNA Clogging in Hafnium Oxide Nanopores
Shiyu Li, Shuangshuang Zeng, Chenyu Wen, Laurent Barbe, Maria Tenje, Zhen Zhang, Klas Hjort, Shi‐Li Zhang
Abstract
pore walls. An analytical model based on examining the energy landscape along the DNA translocation trajectory is developed to qualitatively evaluate the DNA-pore interaction. Both experimental and theoretical results indicate that the occurrence of clogging is strongly dependent on the configuration of translocating DNA molecules and the electrostatic interaction between DNA and charged pore surface. These findings provide a detailed account of the DNA clogging phenomenon and are of practical interest for DNA sensing based on solid-state nanopores.
Topics & Concepts
CloggingNanoporeMaterials scienceChemical physicsNanotechnologyOxideChemistryHistoryArchaeologyMetallurgyNanopore and Nanochannel Transport StudiesIon-surface interactions and analysisAdvancements in Semiconductor Devices and Circuit Design