Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells
Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J. Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao‐Mejia, Reuben Kapur
Abstract
develop features of chronic myelomonocytic leukemia (CMML) and myeloproliferative neoplasm (MPN), respectively, and combined presence results in AML. We observe increased levels of Morrbid in murine models of CMML, MPN, and AML. Functionally, loss of Morrbid in these models induces increased expression of Bim and cell death in immature and mature myeloid cells, which results in reduced infiltration of leukemic cells in tissues and prolongs the survival of AML mice.
Topics & Concepts
Myeloid leukemiaCancer researchChronic myelomonocytic leukemiaLeukemiaApoptosisDownregulation and upregulationMyeloidProgrammed cell deathBiologyHyperactivationImmunologyBone marrowMyelodysplastic syndromesGeneGeneticsAcute Myeloid Leukemia ResearchCancer-related molecular mechanisms researchImmune Cell Function and Interaction