Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer
Sarah Schmidt, Weldy V. Bonilla, Andrea Reiter, Felix Stemeseder, Theresa Kleissner, Daniel Oeler, Ursula Berka, Ahmed El‐Gazzar, Bettina Kiefmann, Sophie Schulha, Josipa Raguz, Mohamed Habbeddine, Marilies Scheinost, Xiaoping Qing, Henning Lauterbach, Igor Matushansky, Daniel D. Pinschewer, Klaus K. Orlinger
Abstract
T cells with reduced PD-1 expression in the tumor tissues. Together, our results suggest that TT1-E7E6 is a promising therapeutic vaccine for HPV-positive cancers.
Topics & Concepts
Lymphocytic choriomeningitisOncolytic virusCancer researchCD8Cytotoxic T cellImmunotherapyImmunologyCancer immunotherapyVirotherapyMedicineBiologyVirusVirologyImmune systemIn vitroBiochemistryImmunotherapy and Immune ResponsesVirus-based gene therapy researchViral Infections and Outbreaks Research