Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors
Yu‐Hang Yan, Wenfang Li, Wei Chen, Chao Li, Kai-Rong Zhu, Ji Deng, Qing-Qing Dai, Lingling Yang, Zhenling Wang, Guo‐Bo Li
Topics & Concepts
MeropenemPseudomonas aeruginosaChemistryCarbapenemEscherichia coliBacteriaMicrobiologyActive siteIn vivoBacterial outer membraneAntibacterial activityAntibiotic resistanceAntibioticsStereochemistryBiochemistryEnzymeBiologyGeneBiotechnologyGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory Infections