Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia M. Bahrami, Kristina G. Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian M. Piliponsky, Sarah Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Abstract
genome appears poised at the time of injury to initiate regeneration by surviving kidney cells, whereas macrophage accumulation was not detected until about day 7. Thus, we provide evidence for rapid activation of a gene expression signature for regenerative wound healing in the spiny mouse kidney.
Topics & Concepts
Function (biology)FibrosisKidneyRegeneration (biology)Cell biologyBiologyMedicinePathologyEndocrinologyRenal and related cancersPluripotent Stem Cells ResearchMesenchymal stem cell research