Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with in-silico ADMET and docking simulation
Hamdy Khamees Thabet, Yousry A. Ammar, Mohd Imran, Mohamed H. Helal, Saleh I. Alaqel, Ahmed Alshehri, Abida Ash Mohd, Moustafa S. Abusaif, Ahmed Ragab
Topics & Concepts
SitagliptinChemistryThiazoleIn silicoIn vitroSulfonamideDocking (animal)Combinatorial chemistryStereochemistryEnzymeQuinolineDipeptidyl peptidaseConjugated systemIC50Dipeptidyl peptidase-4Context (archaeology)CurcuminBiochemistryDiabetes mellitusType 2 Diabetes MellitusOrganic chemistryType 2 diabetesEndocrinologyPolymerBiologyMedicineNursingPaleontologyGeneDiabetes Treatment and ManagementPeptidase Inhibition and AnalysisOral and gingival health research