The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
Bei Yan, Nian Liu, Jie Li, Jiaoduan Li, Wu Zhu, Yehong Kuang, Xiang Chen, Cong Peng
Abstract
The skin is the main barrier between the human body and the outside world, which not only plays the role of a physical barrier but also functions as the first line of defence of immunology. Langerhans cells (LCs), as dendritic cells (DC) that play an important role in the immune system, are mainly distributed in the epidermis. This review focuses on the role of these epidermal LCs in regulating skin threats (such as microorganisms, ultraviolet radiation and allergens), especially psoriasis. Since human and mouse skin DC subsets share common ontogenetic characteristics, we can further explore the role of LCs in psoriatic inflammation.
Topics & Concepts
PsoriasisEpidermis (zoology)Langerhans cellImmunologyImmune systemHuman skinPathogenesisInflammationBiologyHomeostasisCell biologyAnatomyGeneticsImmunotherapy and Immune ResponsesDermatology and Skin DiseasesT-cell and B-cell Immunology