Direct C–H Thiolation for Selective Cross-Coupling of Arenes with Thiophenols via Aerobic Visible-Light Catalysis
Liang Ge, Jing‐Hao Wang, Tao Lei, Yuanyuan Cheng, Chao Zhou, Yajing Chen, Chen Ye, Bin Chen, Chen‐Ho Tung, Li‐Zhu Wu
Abstract
An aerobic metal-free, visible-light-induced regioselective thiolation of phenols with thiophenols is reported. The cross-coupling protocol exhibits great functional group tolerance and high regioselectivity. Mechanistic studies reveal that the disulfide radical cation plays a crucial role in the visible-light catalysis of aerobic thiolation. Simply controlling the equivalent ratio of substrates enables the selective formation of sulfide or sulfoxide products with high activity in a one-pot reaction.
Topics & Concepts
ChemistryRegioselectivityCatalysisVisible spectrumFunctional groupSulfidePhotochemistrySulfoxideCombinatorial chemistryCoupling reactionOrganic chemistryPolymerPhysicsOptoelectronicsSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsAdvanced Photocatalysis Techniques