Role of appetite hormone dysregulation in the cognitive function among patients with bipolar disorder and major depressive disorder
Mu‐Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Shih‐Jen Tsai, Tung‐Ping Su, Cheng‐Ta Li, Wei-Chen Lin, Pei-Chi Tu, Ya‐Mei Bai
Abstract
Objectives The association of appetite hormones with cognitive function in patients with affective disorders remains unknown.Methods All total, 58 adult patients with bipolar I disorder, 36 with bipolar II disorder, 40 with major depressive disorder were enrolled and age and sex-matched with 40 controls. The levels of appetite hormones leptin, ghrelin, insulin and adiponectin were assessed. Wisconsin Card Sorting Test was used to assess executive function.Results A general linear model, adjusted for demographic data and clinical symptoms, demonstrated the ghrelin levels were higher in patients with bipolar I or II disorder than in those with major depressive disorder and controls (p < 0.001). We also identified a positive correlation of ghrelin level and executive function among patients with bipolar I (p = 0.033) and II (p = 0.027) disorders, but not among those with major depressive disorder and controls.Conclusions Patients with bipolar I or II disorder were more likely to have high levels of ghrelin than patients with major depressive disorder and controls, which may have a positive correlation on the cognitive function of patients with bipolar I or II disorder.