Targeted degradation of ABCG2 for reversing multidrug resistance by hypervalent bispecific gold nanoparticle-anchored aptamer chimeras
Weihua Lu, Jingran Chen, Zhanchen Guo, Yanyan Ma, Zikuan Gu, Zhen Liu
Abstract
Hypervalent bispecific gold nanoparticle-anchored aptamer chimeras (AuNP-APTACs) were designed as a new tool of lysosome-targeting chimeras (LYTACs) for efficient degradation of the ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) to reverse multidrug resistance (MDR) of cancer cells. The AuNP-APTACs could effectively increase the accumulation of drugs in drug-resistant cancer cells and provide comparable efficacy to small-molecule inhibitors. Thus, this new strategy provides a new way to reverse MDR, holding great promise in cancer therapy.
Topics & Concepts
AptamerMultiple drug resistanceAbcg2ChemistryHypervalent moleculeColloidal goldCancer researchNanotechnologyATP-binding cassette transporterBiologyMolecular biologyBiochemistryTransporterNanoparticleMaterials scienceReagentAntibioticsPhysical chemistryGeneAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDrug Transport and Resistance Mechanisms