Photo-triggered tandem cyclization of arylethynyl quinazolin-4(3<i>H</i>)-one for difluoroalkylated quinolino[2,1-<i>b</i>]quinazolines
Haibo Yao, Qiang Liu, Jinwei Yuan, Weixian Lv, Liangru Yang, Yongmei Xiao, Yuntao Xia, Dajun Xing
Abstract
An approach to the synthesis of difluoroalkylated quinolino[2,1- b ]quinazolinones has been developed using unactivated alkynes containing quinazolinones and ethyl iododifluoroacetate or iododifluoramides under visible light irradiation.
Topics & Concepts
TandemChemistryCascade reactionCascadeCombinatorial chemistrySubstrate (aquarium)Intramolecular forceReaction conditionsScope (computer science)Transformation (genetics)StereochemistryMedicinal chemistryPhotochemistryReaction mechanismDual (grammatical number)Quinazolinone synthesis and applicationsFluorine in Organic ChemistrySynthesis and Biological Evaluation