The radish Ogura fertility restorer impedes translation elongation along its cognate CMS-causing mRNA
Chuande Wang, Lina Lezhneva, Nadège Arnal, Martine Quadrado, Hakim Mireau
Abstract
Significance Nucleo-cytoplasmic male sterilities (CMS) are two-component genetic systems in which mitochondria-encoded male sterility transcripts are controlled through the action of nuclear-encoded restorer-of-fertility proteins. Fertility restorers most often impact the accumulation of CMS transcripts. In this analysis, we demonstrate that fertility restoration in the Ogura system from radish operates through a specific blockade of ribosome progression along the orf138 CMS transcript. Our analysis reveals that CMS transcripts can be controlled at the translational level, a discovery that will be instrumental to produce custom synthetic fertility restorers.
Topics & Concepts
BiologyCytoplasmic male sterilityGeneticsGeneMessenger RNASterilityTranslation (biology)Nuclear geneCell biologyMitochondrial DNAPhotosynthetic Processes and MechanismsPlant Reproductive BiologyPlant Molecular Biology Research