Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis
Arunima Jaiswal, Aruna S. Jaiswal, Elizabeth A. Williamson, Jonathon Gelfond, Guangrong Zheng, Daohong Zhou, Robert Hromas
Topics & Concepts
ProteolysisCancer researchLeukemiaApoptosisBcl-xLLymphoblastic LeukemiaMedicineImmunologyBiologyOncologyProgrammed cell deathGeneticsBiochemistryEnzymeProtein Degradation and InhibitorsCell death mechanisms and regulationPeptidase Inhibition and Analysis