Formation of N−P(O)−S Bonds from White Phosphorus via a Four‐Component Reaction
Yue Zhang, Yinwei Cao, Yangyang Chi, Shuanghui Chen, Xiangzhe Zeng, Yan Liu, Guo Tang, Yufen Zhao
Abstract
Abstract Functionalization of white phosphorus with disulfides, amines and KOH to phosphoramidodithioates containing both P−N, P−S and P=O bonds via a four‐component reaction is presented. It proceeds with high yields and provides an attractive approach for the construction of valuable N−P(O)−S motif using a one‐step strategy. The advantages of this newly developed process include a clean reaction profile, complete conversion of white phosphorus, transition metal‐free and halogen‐free environmentally benign system, and large‐scale synthetic application. Besides, phosphoramidodithioates can also be utilized to construct P−C, P−O and P=S bonds with the appropriate reagents. magnified image