A Unified Approach for the Synthesis of Isourea and Isothiourea from Isonitrile and <i>N,N</i>-Dibromoarylsulfonamides
Debashish Mishra, Prodeep Phukan
Abstract
A unified approach has been developed for the synthesis of both isourea and isothiourea in a three-component coupling reaction by treating alcohols or thiols respectively with N,N-dibromoarylsulfonamides and isonitrile and in the presence of K2CO3. This metal-free process proceeds via carbodiimide intermediate at room temperature within a very short reaction time. A library of sulfonylisoureas and isothioureas has been made using this synthetic protocol with wide substrate scope in good to high yields.
Topics & Concepts
ChemistryCarbodiimideSubstrate (aquarium)Combinatorial chemistryScope (computer science)Coupling reactionMedicinal chemistryStereochemistryOrganic chemistryCatalysisOceanographyGeologyProgramming languageComputer scienceChemical Synthesis and ReactionsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques