The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin 1/Atg6-mediated lethal autophagy in polyploid cells
Jing Zhang, Shenqiu Zhang, Qiong Shi, Thaddeus D. Allen, Fengming You, Dun Yang
Topics & Concepts
BiologyAutophagySynthetic lethalityMultinucleateApoptosisProgrammed cell deathCancer researchBcl-xLCancer cellKinaseAurora inhibitorCell biologyGeneCancerGeneticsCell cycleDNA repairMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysAutophagy in Disease and Therapy