Direct Chiral Discrimination with NMR
Sagar Wadhwa, Dominique Buyens, Jan G. Korvink
Abstract
Unaided nuclear magnetic resonance (NMR) spectroscopy is considered incapable of distinguishing enantiomers. However, as first derived by A.D. Buckingham, the tensor coupling the electric and magnetic dipoles is space-dependent, which varies according to the molecular structure, hence, would be different for two enantiomers. Exploiting the odd-parity coupling tensor, a new variant of a double-resonant radiofrequency (RF) NMR detector is developed, which is sensitive to both electric and magnetic dipoles. Using the detector, a new method for liquid-state NMR is developed and elaborated, with which two enantiomers are successfully discriminated.
Topics & Concepts
EnantiomerNuclear magnetic resonance spectroscopyTensor (intrinsic definition)Nuclear magnetic resonanceMagnetic dipole–dipole interactionMaterials scienceCoupling (piping)DipoleDetectorTwo-dimensional nuclear magnetic resonance spectroscopyPhysicsChemistryStereochemistryOpticsQuantum mechanicsMathematicsPure mathematicsMetallurgyMolecular spectroscopy and chiralityAdvanced NMR Techniques and ApplicationsNMR spectroscopy and applications