Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic
Denise B. Catacutan, Vian Tran, Autumn Arnold, Jeremie Alexander, Gabriele Corso, Yeganeh Yousefi, Megan M. Tu, Stewart McLellan, Dominique Tertigas, Kimberly Corneil, Jakob Magolan, Michael G. Surette, Eric D. Brown, Brian K. Coombes, Regina Barzilay, J Stokes
Topics & Concepts
AntibioticsPolymyxinBiologyEscherichia coliMicrobiologyBacterial outer membraneMicrobiomeDysbiosisPathogenAntibacterial activityEnterobacteriaceaeDrug resistancePolymyxin BDrug discoveryCytotoxicityBacteriaAntibiotic resistanceHuman pathogenMutantIn vitroDrugHuman microbiomeMultiple drug resistanceComputational biologyAntimicrobialDrug developmentMechanism of actionMembrane permeabilityAntibacterial agentShigella flexneriMechanism (biology)Small moleculeMinimum inhibitory concentrationShigellaComputational Drug Discovery MethodsBiosimilars and Bioanalytical MethodsBacterial Identification and Susceptibility Testing