A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing
Alexander I. Taylor, Christopher Wan, Maria J. Donde, Sew‐Yeu Peak‐Chew, Philipp Holliger
Topics & Concepts
ChemistryGene silencingModular designGeneAlleleComputational biologyCell biologyBiochemistryBiologyComputer scienceProgramming languageCRISPR and Genetic EngineeringRNA modifications and cancerRNA and protein synthesis mechanisms